Halle RMN Gif-sur-Yvette
Nom de la plateforme
Institut de Chimie des Substances Naturelles - Plateforme de RMN à hauts champs
Ville
Gif-sur-Yvette
Adresse

1 avenue de la terrasse, 91190, Gif-sur-Yvette

Responsable scientifique
Dr. Ewen Lescop (Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.)
Responsable opérationnel
Dr. Nelly Morellet (Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.)
Correspondant communication
Mr. François Giraud (Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.)
Responsable gestion
Mme Alda Da Costa (Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser., Tel: 01 69 82 36 71)

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La plateforme Infranalytics de Gif-sur-Yvette comprend :


RMN Gif Haute pression 637a1RMN Gif IMG 1779 072df• Un spectromètre 950 MHz Bruker Avance III-HD équipé d'une cryosonde TCI (1H,13C,15N,2H) 5mm, gradients-z (S/B = 9307) travaillant de 0°C à 80°C, compatible tubes ovales (échantillons salins)

• Un équipement « Deadalus inc» pour réaliser des expériences de RMN à haute pression, avec 1 tube en céramique (1 bar à 3 kbar)

Expériences RMN disponibles :
RMN rapide (BEST, SOFAST, ...), Méthodes d’échantillonnage non linéaire ou de projection, Expérience triple résonance 3D, 4D pour protéines et acides nucléiques, Relaxation et Dispersion de Relaxation, Couplages Dipolaires Résiduels, RMN des méthyls, Interactions Protéines ligands, DOSY, RMN paramagnétique (PRE/PCS).

Domaines principaux d'application :
Structure, dynamique et interactions des macromolécules biologiques ; petites molécules en faible quantité (produits naturels).

 
 
 
Resp. Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser. (33-(0)169823764) ; Corr. Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser. (33-(0)169823762) ; Secr-gestion Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser. (33-(0)169823671)

Équipement

BRUKER Avance III HD 950

Description
Ultrastabilized and ultrashielded Narrow Bore Magnet 950/54 @ 22.31T. Avance III HD generation console of electronics (4 channels). TopSpin 3.6 user interface.
Spécificités
High pressure apparatus (1-3000 bar)
Sondes de mesure

Triple resonance liquid state z-gradient ATMA probes:

  • TCI cryoprobe
  • TXI classical probe
Expertises et services
  • Conception de projets d’étude structurale par RMN adaptés aux systèmes et questions posées et accompagnement des équipes à chaque étape : attribution de résonances, étude de dynamique, détermination de structures 3D, interactions, titrages, cinétiques...
  • Réalisation d’expériences de RMN multi-noyaux (1H, 2H, 13C, 15N, 19F, 31P), RMN rapide (BEST, SOFAST, ...), RMN paramagnétique et haute pression
  • Utilisation de méthodes d’échantillonnage non linéaire ou de projections
  • Réalisation d’expériences triple résonance 3D et 4D pour protéines et acides nucléiques
  • Réalisation d’expériences de relaxation, dispersion de relaxation, couplage dipolaire résiduel et diffusion (DOSY)
  • Enregistrement de spectres RMN spécifiques des méthyls
  • Enregistrement d’expériences RMN pour la caractérisation d’interactions protéine-ligand
  • Analyse et interprétation de données avec formation des utilisateurs
  • Mise à disposition de spectromètres avec accompagnement pour utilisateurs avertis.
Autres équipements

plateforme-rmn-gif-2.jpg

Le spectromètre 950MHz est intégré dans la plateforme RMNHC@UPSAY, noeud RMN de l'infrastructure FRISBI (French Research Integrated Structural Biology Infrastructure), labélisée IBISA, dont 5 des 6 spectromètres sont actuellement gérés par l’équipe "RMN, Biologie et Chimie Structurales" de l’Institut de Chimie des Substances Naturelles, sur le campus CNRS de Gif-sur-Yvette. La recherche sur le campus est essentiellement centrée sur la chimie et la biologie, avec une forte composante de biologie structurale dans un contexte biologie et santé. Le campus de Gif est intégré dans le « grand campus Paris-Saclay » (https://www.universite-paris-saclay.fr/), qui regroupe plus de 10000 chercheurs de tous les horizons scientifiques, et une forte communauté de chercheurs en biologie structurale (Gif-sur-Yvette, Université Paris 11, le CEA à Saclay et le synchrotron SOLEIL).

800 MHz Bruker Avance III Liquide

Sonde liquide:
Cryo TCI (1H, 13C, 15N, 2H), 5mm, z-gradients

700 MHz Bruker Avance NEO Liquide

Sonde liquide TXO (1H, 13C, 15N, 2H), 5mm, z-gradients

600 MHz (Bruker-1) Bruker Avance III Liquide

Sondes liquides:

  • Cryo TCI (1H, 13C, 15N, 2H), 5mm, z-gradients
  • Cryo QCI (1H, 13C, 15N, 19F, 2H), 5mm, z-gradients
  • Passeur d’échantillon SampleJet (avec régulation de température)

600 MHz (Bruker-2) Bruker Avance III Liquide

Sondes liquides:

  • TXI (1H, 13C, 15N, 2H), 5mm, x,y,z-gradients
  • TBI (1H, 13C BB), 5mm, x,y,z-gradients

De plus, un service de RMN est à la disposition des chimistes, avec un 600MHz, deux 500MHz et deux 300MHz.

Quelques publications récentes

Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure.

Pozza A, Giraud F, Cece Q, Casiraghi M, Point E, Damian M, Le Bon C, Moncoq K, Banères J-L, Lescop E, Catoire L J. Nat Commun. 2022 Apr 1;13(1):1780. doi: 10.1038/s41467-022-29410-5. Online ahead of print. PMID: 35365643

Optimisation of spatially-encoded diffusion-ordered NMR spectroscopy for the analysis of mixtures.

Jacquemmoz C, Mishra R, Guduff L, van Heijenoort C, Dumez JN. Magn Reson Chem. 2022 Jan;60(1):121-138. doi: 10.1002/mrc.5194. Epub 2021 Sep 2. PMID: 34269476

Nuclear Magnetic Resonance Spectroscopy: A Multifaceted Toolbox to Probe Structure, Dynamics, Interactions, and Real-Time In Situ Release Kinetics in Peptide-Liposome Formulations.  

Doyen C, Larquet E, Coureux PD, Frances O, Herman F, Sablé S, Burnouf JP, Sizun C, Lescop E. Mol Pharm. 2021 Jul 5;18(7):2521-2539. doi: 10.1021/acs.molpharmaceut.1c00037. Epub 2021 Jun 20. PMID: 34151567

Revisiting the Molecular Interactions between the Tumor Protein TCTP and the Drugs Sertraline/Thioridazine.  

Malard F, Jacquet E, Nhiri N, Sizun C, Chabrier A, Messaoudi S, Dejeu J, Betzi S, Zhang X, Thureau A, Lescop E. ChemMedChem. 2022 Jan 5;17(1):e202100528. doi: 10.1002/cmdc.202100528. Epub 2021 Oct 6. PMID: 344727

Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain.

Mouhand A, Zargarian L, Belfetmi A, Catala M, Pasi M, Lescop E, Tisné C, Mauffret O. Viruses. 2022 Mar 18;14(3):632. doi: 10.3390/v14030632. PMID: 35337039

Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals.  

Decool H, Gonnin L, Gutsche I, Sizun C, Eléouët JF, Galloux M. Viruses. 2021 Dec 6;13(12):2449. doi: 10.3390/v13122449. PMID: 34960719

Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs.  

Pinet L, Assrir N, van Heijenoort C. Biomolecules. 2021 Nov 14;11(11):1690. doi: 10.3390/biom11111690. PMID: 34827688

Relationships between RNA topology and nucleocapsid structure in a model icosahedral virus.

Marichal L, Gargowitsch L, Rubim RL, Sizun C, Kra K, Bressanelli S, Dong Y, Panahandeh S, Zandi R, Tresset G. Biophys J. 2021 Sep 21;120(18):3925-3936. doi: 10.1016/j.bpj.2021.08.021. Epub 2021 Aug 19. PMID: 34418368

β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation.

Lesma J, Bizet F, Berardet C, Tonali N, Pellegrino S, Taverna M, Khemtemourian L, Soulier JL, van Heijenoort C, Halgand F, Ha-Duong T, Kaffy J, Ongeri S. Front Cell Dev Biol. 2021 Sep 16;9:729001. doi: 10.3389/fcell.2021.729001. eCollection 2021. PMID: 34604227

A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein.  

Cardone C, Caseau CM, Bardiaux B, Thureaux A, Galloux M, Bajorek M, Eléouët JF, Litaudon M, Bontems F, Sizun C. Biomolecules. 2021 Aug 17;11(8):1225. doi: 10.3390/biom11081225. PMID: 34439894

The unusual structure of the PiggyMac cysteine-rich domain reveals zinc finger diversity in PiggyBac-related transposases.

Guérineau M, Bessa L, Moriau S, Lescop E, Bontems F, Mathy N, Guittet E, Bischerour J, Bétermier M, Morellet N. Mob DNA. 2021 Apr 29;12(1):12. doi: 10.1186/s13100-021-00240-4. PMID: 33926516

Structural and dynamic characterization of the C-terminal tail of ErbB2: Disordered but not random.

Pinet L, Wang YH, Deville C, Lescop E, Guerlesquin F, Badache A, Bontems F, Morellet N, Durand D, Assrir N, van Heijenoort C. Biophys J. 2021 Mar 17:S0006-3495(21)00234-4. doi: 10.1016/j.bpj.2021.03.005. Online ahead of print. PMID: 33741354

Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL-1.

Daressy F, Malard F, Seguy L, Guérineau V, Apel C, Dumontet V, Robert A, Groo AC, Litaudon M, Bignon J, Desrat S, Malzert-Fréon A, Wiels J, Lescop E, Roussi F. ChemMedChem. 2021 Mar 5. doi: 10.1002/cmdc.202100011. Online ahead of print. PMID: 33665938

Pneumoviral Phosphoprotein, a Multidomain Adaptor-Like Protein of Apparent Low Structural Complexity and High Conformational Versatility.

Cardone C, Caseau CM, Pereira N, Sizun C. Int J Mol Sci. 2021 Feb 3;22(4):1537. doi: 10.3390/ijms22041537. PMID: 33546457 Free PMC article. Review.

Fluorinated Triazole Foldamers: Folded or Extended Conformational Preferences.

Laxio Arenas J, Xu Y, Milcent T, Van Heijenoort C, Giraud F, Ha-Duong T, Crousse B, Ongeri S. Chempluschem. 2021 Feb;86(2):241-251. doi: 10.1002/cplu.202000791. PMID: 33555641

Tetramerization of Phosphoprotein is Essential for Respiratory Syncytial Virus Budding while its N Terminal Region Mediates Direct Interactions with the Matrix Protein.

Bajorek M, Galloux M, Richard CA, Szekely O, Rosenzweig R, Sizun C, Eleouet JF. J Virol. 2021 Jan 6:JVI.02217-20. doi: 10.1128/JVI.02217-20. Online ahead of print. PMID: 33408180

Nonsymmetrical Dynamics of the HBV Capsid Assembly and Disassembly Evidenced by Their Transient Species.

Chevreuil M, Lecoq L, Wang S, Gargowitsch L, Nhiri N, Jacquet E, Zinn T, Fieulaine S, Bressanelli S, Tresset G. J Phys Chem B. 2020 Nov 12;124(45):9987-9995. doi: 10.1021/acs.jpcb.0c05024. Epub 2020 Nov 2. PMID: 33135897

A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP.

Munoz-Montesino C, Larkem D, Barbereau C, Igel-Egalon A, Truchet S, Jacquet E, Nhiri N, Moudjou M, Sizun C, Rezaei H, Béringue V, Dron M. J Biol Chem. 2020 Oct 9;295(41):14025-14039. doi: 10.1074/jbc.RA120.014738. Epub 2020 Aug 11. PMID: 32788216 Free article.

Cyclodextrin complexation studies as the first step for repurposing of chlorpromazine.

Wang Z, Landy D, Sizun C, Cézard C, Solgadi A, Przybylski C, de Chaisemartin L, Herfindal L, Barratt G, Legrand FX. Int J Pharm. 2020 Jun 30;584:119391. doi: 10.1016/j.ijpharm.2020.119391. Epub 2020 May 4. PMID: 32376444

NMR Characterization of the Influence of Zinc(II) Ions on the Structural and Dynamic Behavior of the New Delhi Metallo-β-Lactamase-1 and on the Binding with Flavonols as Inhibitors.

Rivière G, Oueslati S, Gayral M, Créchet JB, Nhiri N, Jacquet E, Cintrat JC, Giraud F, van Heijenoort C, Lescop E, Pethe S, Iorga BI, Naas T, Guittet E, Morellet N. ACS Omega. 2020 Apr 28;5(18):10466-10480. doi: 10.1021/acsomega.0c00590. eCollection 2020 May 12. PMID: 32426604 Free PMC article.

Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch.

Ye SX, Gong Z, Yang J, An YX, Liu Z, Zhao Q, Lescop E, Dong X, Tang C. Protein Cell. 2019 Dec;10(12):908-913. doi: 10.1007/s13238-019-0644-x. PMID: 31278634 Free PMC article. No abstract available.

Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome.

Arrondel C, Missoury S, Snoek R, Patat J, Menara G, Collinet B, Liger D, Durand D, Gribouval O, Boyer O, Buscara L, Martin G, Machuca E, Nevo F, Lescop E, Braun DA, Boschat AC, Sanquer S, Guerrera IC, Revy P, Parisot M, Masson C, Boddaert N, Charbit M, Decramer S, Novo R, Macher MA, Ranchin B, Bacchetta J, Laurent A, Collardeau-Frachon S, van Eerde AM, Hildebrandt F, Magen D, Antignac C, van Tilbeurgh H, Mollet G. Nat Commun. 2019 Sep 3;10(1):3967. doi: 10.1038/s41467-019-11951-x. PMID: 31481669 Free PMC article.

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin.

Gervason S, Larkem D, Mansour AB, Botzanowski T, Müller CS, Pecqueur L, Le Pavec G, Delaunay-Moisan A, Brun O, Agramunt J, Grandas A, Fontecave M, Schünemann V, Cianférani S, Sizun C, Tolédano MB, D'Autréaux B. Nat Commun. 2019 Aug 8;10(1):3566. doi: 10.1038/s41467-019-11470-9. PMID: 31395877 Free PMC article.

Natural Chlordecone Degradation Revealed by Numerous Transformation Products Characterized in Key French West Indies Environmental Compartments.

Chevallier ML, Della-Negra O, Chaussonnerie S, Barbance A, Muselet D, Lagarde F, Darii E, Ugarte E, Lescop E, Fonknechten N, Weissenbach J, Woignier T, Gallard JF, Vuilleumier S, Imfeld G, Le Paslier D, Saaidi PL. Environ Sci Technol. 2019 Jun 4;53(11):6133-6143. doi: 10.1021/acs.est.8b06305. Epub 2019 May 22. PMID: 31082212

YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis.

Kretov DA, Clément MJ, Lambert G, Durand D, Lyabin DN, Bollot G, Bauvais C, Samsonova A, Budkina K, Maroun RC, Hamon L, Bouhss A, Lescop E, Toma F, Curmi PA, Maucuer A, Ovchinnikov LP, Pastré D. Nucleic Acids Res. 2019 Apr 8;47(6):3127-3141. doi: 10.1093/nar/gky1303. PMID: 30605522 Free PMC article.

Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25.

Jeanne Dit Fouque K, Hegemann JD, Zirah S, Rebuffat S, Lescop E, Fernandez-Lima F. J Am Soc Mass Spectrom. 2019 Jun;30(6):1038-1045. doi: 10.1007/s13361-019-02134-5. Epub 2019 Mar 4. PMID: 30834511

Structural Characterization of N-WASP Domain V Using MD Simulations with NMR and SAXS Data.

Chan-Yao-Chong M, Deville C, Pinet L, van Heijenoort C, Durand D, Ha-Duong T. Biophys J. 2019 Apr 2;116(7):1216-1227. doi: 10.1016/j.bpj.2019.02.015. Epub 2019 Feb 26. PMID: 30878202 Free PMC article.

Single-Scan Diffusion-Ordered NMR Spectroscopy of SABRE-Hyperpolarized Mixtures.

Guduff L, Berthault P, van Heijenoort C, Dumez JN, Huber G. Chemphyschem. 2019 Feb 4;20(3):392-398. doi: 10.1002/cphc.201800983. Epub 2019 Jan 4. PMID: 30521115

Abou Samra, A., A. Robert, C. Gov, L. Favre, L. Eloy, E. Jacquet, J. Bignon, J. Wiels, S. Desrat and F. Roussi (2018). "Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A." Eur J Med Chem 148: 26-38.

Andre, E., V. Derrien, P. Sebban, N. Assrir, E. Lescop and S. Bernad (2018). "Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics." J Biol Inorg Chem.

Casiraghi, M., M. Damian, E. Lescop, J. L. Baneres and L. J. Catoire (2018). "Illuminating the Energy Landscape of GPCRs: The Key Contribution of Solution-State NMR Associated with Escherichia coli as an Expression Host." Biochemistry 57(16): 2297-2307.

Cavailles, M., A. Bornet, X. Jaurand, B. Vuichoud, D. Baudouin, M. Baudin, L. Veyre, G. Bodenhausen, J. N. Dumez, S. Jannin, C. Coperet and C. Thieuleux (2018). "Tailored Microstructured Hyperpolarizing Matrices for Optimal Magnetic Resonance Imaging." Angew Chem Int Ed Engl 57(25): 7453-7457.

Concilio, M. G., C. Jacquemmoz, D. Boyarskaya, G. Masson and J. N. Dumez (2018). "Ultrafast Maximum-Quantum NMR Spectroscopy for the Analysis of Aromatic Mixtures." Chemphyschem.

Dumez, J. N. (2018). "Spatial encoding and spatial selection methods in high-resolution NMR spectroscopy." Prog Nucl Magn Reson Spectrosc 109: 101-134.

Dumez, J. N. (2018). "Hyperpolarized magnetic resonance in chemistry." Magn Reson Chem 56(7): 565.

Gicquel, M., C. Gomez, M. C. Garcia Alvarez, O. Pamlard, V. Guerineau, E. Jacquet, J. Bignon, A. Voituriez and A. Marinetti (2018). "Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3'-Spirocyclopentene Oxindole Derivatives." J Med Chem 61(20): 9386-9392.

Grzela, R., J. Nusbaum, S. Fieulaine, F. Lavecchia, M. Desmadril, N. Nhiri, A. Van Dorsselaer, S. Cianferani, E. Jacquet, T. Meinnel and C. Giglione (2018). "Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts." Biochim Biophys Acta Proteins Proteom 1866(2): 348-355.

Hamdoun, G., L. Guduff, C. van Heijenoort, C. Bour, V. Gandon and J. N. Dumez (2018). "Spatially encoded diffusion-ordered NMR spectroscopy of reaction mixtures in organic solvents." Analyst 143(14): 3458-3464.

Huber, G., L. Guduff, P. Berthault, C. van Heijenoort and J. N. Dumez (2018). "Single-scan diffusion-ordered NMR spectroscopy of SABRE-hyperpolarized mixtures." Chemphyschem.

Jacquemmoz, C. and J. N. Dumez (2018). "Acceleration of 3D DOSY NMR by Spatial Encoding of the Chemical Shift." Chemphyschem.

Malard, F., N. Assrir, M. Alami, S. Messaoudi, E. Lescop and T. Ha-Duong (2018). "Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation." J Mol Biol 430(11): 1621-1639.

Molina, C. E., E. Jacquet, P. Ponien, C. Munoz-Guijosa, I. Baczko, L. S. Maier, P. Donzeau-Gouge, D. Dobrev, R. Fischmeister and A. Garnier (2018). "Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart." Cardiovasc Res 114(2): 247-258.

Mons, C., T. Botzanowski, A. Nikolaev, P. Hellwig, S. Cianferani, E. Lescop, C. Bouton and M. P. Golinelli-Cohen (2018). "The H2O2-Resistant Fe-S Redox Switch MitoNEET Acts as a pH Sensor To Repair Stress-Damaged Fe-S Protein." Biochemistry 57(38): 5616-5628.

Morellet, N., X. Li, S. A. Wieninger, J. L. Taylor, J. Bischerour, S. Moriau, E. Lescop, B. Bardiaux, N. Mathy, N. Assrir, M. Betermier, M. Nilges, A. B. Hickman, F. Dyda, N. L. Craig and E. Guittet (2018). "Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase." Nucleic Acids Res 46(5): 2660-2677.

Mouhand, A., A. Belfetmi, M. Catala, V. Larue, L. Zargarian, F. Brachet, R. J. Gorelick, C. Van Heijenoort, G. Mirambeau, P. Barraud, O. Mauffret and C. Tisne (2018). "Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis." Nucleic Acids Res 46(18): 9699-9710.

Petitalot, A., E. Dardillac, E. Jacquet, N. Nhiri, J. Guirouilh-Barbat, P. Julien, I. Bouazzaoui, D. Bonte, J. Feunteun, J. A. Schnell, P. Lafitte, J. C. Aude, C. Nogues, E. Rouleau, R. Lidereau, B. S. Lopez, S. Zinn-Justin, S. M. Caputo and U. G. G. B. network (2018). "Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk." Mol Cancer Res.

Plainchont, B., P. Berruyer, J. N. Dumez, S. Jannin and P. Giraudeau (2018). "Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry." Anal Chem 90(6): 3639-3650.

Richard, C. A., V. Rincheval, S. Lassoued, J. Fix, C. Cardone, C. Esneau, S. Nekhai, M. Galloux, M. A. Rameix-Welti, C. Sizun and J. F. Eleouet (2018). "RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription." PLoS Pathog 14(3): e1006920.

Rochat, T., C. Bohn, C. Morvan, T. N. Le Lam, F. Razvi, A. Pain, C. Toffano-Nioche, P. Ponien, A. Jacq, E. Jacquet, P. D. Fey, D. Gautheret and P. Bouloc (2018). "The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus." Nucleic Acids Res 46(17): 8803-8816.

Romano, M., G. Fusco, H. G. Choudhury, S. Mehmood, C. V. Robinson, S. Zirah, J. D. Hegemann, E. Lescop, M. A. Marahiel, S. Rebuffat, A. De Simone and K. Beis (2018). "Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters." ACS Chem Biol 13(6): 1598-1609.

Samson, C., A. Petitalot, F. Celli, I. Herrada, V. Ropars, M. H. Le Du, N. Nhiri, E. Jacquet, A. A. Arteni, B. Buendia and S. Zinn-Justin (2018). "Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases." Nucleic Acids Res 46(19): 10460-10473.

Tonali, N., J. Kaffy, J. L. Soulier, M. L. Gelmi, E. Erba, M. Taverna, C. van Heijenoort, T. Ha-Duong and S. Ongeri (2018). "Structure-activity relationships of beta-hairpin mimics as modulators of amyloid beta-peptide aggregation." Eur J Med Chem 154: 280-293.

Assrir, N., F. Malard and E. Lescop (2017). "Structural Insights into TCTP and Its Interactions with Ligands and Proteins." Results Probl Cell Differ 64: 9-46.

Dumez, J. N. (2017). "Perspectives on hyperpolarised solution-state magnetic resonance in chemistry." Magn Reson Chem 55(1): 38-46.

Dumez, J. N., B. Vuichoud, D. Mammoli, A. Bornet, A. C. Pinon, G. Stevanato, B. Meier, G. Bodenhausen, S. Jannin and M. H. Levitt (2017). "Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups." J Phys Chem Lett 8(15): 3549-3555.

Grzela, R., J. Nusbaum, S. Fieulaine, F. Lavecchia, M. Desmadril, N. Nhiri, A. Van Dorsselaer, S. Cianferani, E. Jacquet, T. Meinnel and C. Giglione (2018). "Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts." Biochim Biophys Acta Proteins Proteom 1866(2): 348-355.

Guduff, L., A. J. Allami, C. van Heijenoort, J. N. Dumez and I. Kuprov (2017). "Efficient simulation of ultrafast magnetic resonance experiments." Phys Chem Chem Phys 19(27): 17577-17586.

Guduff, L., I. Kuprov, C. van Heijenoort and J. N. Dumez (2017). "Spatially encoded 2D and 3D diffusion-ordered NMR spectroscopy." Chem Commun (Camb) 53(4): 701-704.

Guduff, L., D. Kurzbach, C. van Heijenoort, D. Abergel and J. N. Dumez (2017). "Single-Scan (13) C Diffusion-Ordered NMR Spectroscopy of DNP-Hyperpolarised Substrates." Chemistry 23(66): 16722-16727.

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