Online coupling between separation techniques (liquid and gas chromatography or capillary electrophoresis) and Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) requires trade-offs and does not seem as straightforward as coupling with other type analysisurs (time of flight or quadrupole for example).

Indeed, FT-ICR mass spectrometry needs time to reach its highest resolving power and mass measurement accuracy, whereas the chromatographic and electrophoretic peaks are only transient.

Even though the implementation of FT-ICR MS coupled with in-line separation methods is a bit trickier (the art of compromise), this review shows that it provides unparalleled results to the scientific community (the art of the possible), while raising the question of its future.

To know more : 

Hyphenation of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) with separation methods: The art of compromises and the possible - A review

Clarisse Gosset-Erard^{a, b}, Frederic Aubriet^a, Emmanuelle Leize-Wagner^b, Yannis-Nicolas Francois^b, Patrick Chaimbault^a*

^a University of Lorraine, LCP-A2MC, F-57000, Metz, France

^b Interactions and Systems Mass Spectrometry Laboratory (LSMIS) UMR 7140 (Unistra-CNRS), University of, Strasbourg, France

Talenta, volume 257, 15 May 2023, 124324.

https://doi.org/10.1016/j.talanta.2023.124324